پروژه های آماده دارو سازی

این پروژه یک مقاله آماده با موضوع، افزایش انحلال سیلیمارین با کاهش اندازه ذرات به مقیاس نانو از طریق فناوری میکروفلوئیدیک در ۲۱ صفحه ورد می باشد. در ادامه چکیده ای از این مقاله را خواهیم داشت: چکیده: Enhancement of Silymarin Dissolution by Particle Size Reduction to the Nanoscale via Microfluidic Technology   Abstract This paper was aimed at increasing the solubility and dissolution rate of a poorly soluble BCS Class IV drug, silymarin, by using microfluidic-assisted nanoprecipitation in the presence of polyvinylpyrrolidone (PVP) as a stabilizing polymer. The Box-Behnken experimental design was utilized to optimize the process parameters and the program took into account the drug concentration, polymer concentration, and antisolvent-solvent (AS/S) ratio as the most important variables. Optimal formulation resulted in homogenous silymarin-PVP nanoparticles of average diameter of approximately 100 nm, slight polydispersity (PDI [?] 0.10) and high stability. Physicochemical characterization Silymarin was successfully amorphized by thorough physicochemical characterization. SEM analysis provided discrete, smooth-surfaced, spherical nanoparticles with smooth surfaces whereas XRD and DSC analysis revealed that all crystalline silymarin peaks vanished thus indicating the amorphous state of the nanoparticles. The FTIR spectra required some characteristic shifts of the PVP carbonyl group (1660 -1642 cm-1), which was the result of hydrogen-bonding between the drug and polymer and contributed to thermodynamic stabilization and recrystallization prohibition. Investigations into dissolution showed that 90 percent of silymarin dissolved in 120 minutes, as compared to only 18 percent in case of the pure drug. The kinetics of dissolution obeyed a Korsmeyer-Peppas law implying that non-Fickian diffusion and polymer relaxation were the dominant processes. DOE statistical analysis showed that nanoparticle size was highly correlated with polymer concentration and ratio of flow rate as evidence of the high precision and reproducibility of the microfluidic technique. Altogether, the research confirms microfluidic nanoprecipitation as an effective and scalable system to prepare amorphous nanodrug delivery systems. The resultant silymarin-PVP nanoparticles possessed increased solubility, increased kinetics of dissolution, and better stability- provide an excellent solution to biopharmaceutical issues of BCS Class IV drugs and enhance their oral bioavailability. Keywords: Silymarin, Microfluidic Nanoprecipitation, Polyvinylpyrrolidone (PVP), Amorphous Nanoparticles Dissolution Enhancement.