پروژه های آماده پزشکی

این پروژه یک مقاله آماده با موضوع، تأثیر استرس مزمن ناشی از خشونت علیه شریک جنسی بر اختلال در تنظیم سیستم ایمنی زنان و حساسیت به عفونت‌ها در ۱۵ صفحه ورد می باشد. در ادامه چکیده ای از این مقاله را خواهیم داشت: چکیده: impact of chronic stress from intimate partner violence on women’s immune dysregulation and susceptibility to infections   Abstract Background in intimate partner violence (IPV), it is a widespread health crisis globally with almost every third woman facing it. In addition to its psychological effect, there is emerging evidence indicating that IPV is a chronic biological stressor, which results in hypothalamic-pituitary-adrenal (HPA) axis dysregulation, cortisol secretion and immune system impairment. Such physiological dysfunction leads to greater inflammation, poor immunity and higher vulnerability to infections with a dire need of comprehending IPV as a biopsychosocial and immunological syndrome and not just a social one. Purpose: This narrative review attempted to integrate new evidence (2022-2025) into the role of chronic stress due to IPV in immune regulation and vulnerability to infection in women combining the results obtained in psychoneuroendocrinological, immunological, and epigenetic frameworks. The research question was as follows: How does chronic stress caused by IPV lead to immune malfunction and predisposition to infection in women? Methods: An extensive search was performed in PubMed, Embase, Cochrane Library, Scopus and Web of Science through November 2025. Peer-reviewed studies were used as inclusion criteria, and they had to involve adult women who were exposed to IPV and tested biological effects, including inflammatory cytokines, HPA axis alterations, or an infection risk. Excluding criteria were non-IPV-related stress, lack of biomarkers in the qualitative data, or male or children. Newcastle-Ottawa Scale and ROBINS-I were used to assess the risk of bias, and the synthesis was performed in the form of a narrative because of methodological heterogeneity. Findings: 20 studies were included in the study, which included more than 18,000 women in 16 countries. Exposure to IPV was regularly linked to increased IL- 6, CRP, and TNF-a, BP silenced cortisol rhythms, and epigenetic adaptations of stress-relevant genes (e.g., NR3C1, BDNF). Intergenerational immune effects were also found as IPV in the course of pregnancy is a predictor of further infection in infants. Conclusion: IPV represents a biologically implanted long-term inflammatory disorder that biologically implants stress via neuroendocrine and epigenetic pathways and impairs immune resilience. Incorporation of biological screening and trauma-informed treatment into the IPV-driven care is necessary to reduce its long-term immunological and infectious impact on the health of women. Keywords: Intimate Partner Violence; Chronic Stress; Immune Dysregulation; Inflammation; Women Health.